list1 = [] with open('fmi-imageless.txt', 'r') as file: for uri in file: uri = uri[:-1] # remove \n list1.append(uri) list2 = [] with open('wlm-fmi-imageless.txt', 'r') as file: for uri in file: uri = uri[:-1] # remove \n list2.append(uri) list1 = set(list1) list2 = set(list2) print(len(list1.intersection(list2))) print(list2.issubset(list1))